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Third-degree burns, also known as full-thickness burns, extend through the entire dermis and can impair the function of hair follicles, sweat glands, and nerves. Because they destroy both the epidermis and the dermis, the body’s natural healing processes are significantly compromised, and these burns typically do not heal on their own. Instead, they require surgical intervention, specifically skin grafting, to facilitate proper healing and restore skin integrity. Skin grafts involve transplanting healthy skin from another part of the patient's body or a donor to cover the damaged area, promoting healing and reducing the risk of complications such as infection.

In contrast, first-degree burns typically involve only the outer layer of skin (epidermis) and generally heal without intervention, while second-degree burns, which affect both the epidermis and part of the dermis, can heal on their own but may require grafting if they are deep and extensive. However, not all second-degree burns require grafting; many heal with conservative management like dressings and proper wound care. Thus, it is the third-degree burns that unequivocally necessitate grafting for healing.